The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5 ...

Germline and somatic sequence variants in non-coding regions can play an important role in cancer. Many different modes of action of non-coding variants are known. For example, point mutations and ...

When regions of the human genome where the DNA can fold into unusual three-dimensional structures called G-quadruplexes (G4s) are located in regulatory sequences or other functional, but non-protein ...

Researchers at the University of Toronto have mapped the spatial distribution of around 700 long non-coding RNAs, otherwise known as lncRNAs, in the testes. The team discovered much higher levels of ...