Transposable elements (TEs) form 50% of the mammalian genome sequence, and their expression contributes to processes from development to disease. Owing to the abundance and high sequence similarity of ...

Nanopore signal analysis enables detection of nucleotide modifications from native DNA and RNA sequencing, providing both accurate genetic or transcriptomic and epigenetic information without ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

High background noise in RNA samples can impact read accuracy and increase sequencing costs. Optimizing sample quality enables better microRNA mapping and more reliable insights in transcriptomics and ...

CIPHER-seq—short for Cytokine Intracellular Protein High-throughput Expression with RNA sequencing—was built to close that gap. The method allows researchers to gently preserve cells, enabling them to ...

SINGAPORE – Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called ‘sm-PORE-cupine’, to study individual RNA molecules and reveal how their structures ...

Hospital for Sick Children in Toronto researchers are reporting that targeted RNA sequencing can detect clinically actionable alterations in 87% of tumors and provide decisive findings where DNA-seq ...

National Cancer Institute researchers have developed a method called HORNET for characterizing 3D topological structures of large and flexible RNA molecules. Scientists used atomic force microscopy ...

Morgan Hiebert (left) studies drug-resistant tuberculosis within the National Reference Centre for Mycobacteriology (Winnipeg, Manitoba) led by Hafid Soualhine, situated in the National Microbiology ...

An interdisciplinary team of Rice University researchers has uncovered previously unknown relationships between bacteriophages—viruses that infect bacteria—and their bacterial hosts, offering a ...

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come ...